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Hazard Predictions

• Flammable: Reaction products may be flammable
• Generates heat: Exothermic reaction at ambient temperatures (releases heat)
• Toxic: Reaction products may be toxic

The cyanide ion can act as a nucleophile to displace the halide from an acyl halide, resulting in an acyl cyanide (Zeng, Wei et al, Letters in Organic Chemistry, 6(8), 637-641; 2009). Acyl cyanides are reactive compounds which are highly flammable and toxic. Caution should be used before proceeding. Further research of comparable examples in the literature or very small scale, carefully controlled experiments may be needed to fully assess compatibility.