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Hazard Predictions

• Generates gas: Reaction liberates gaseous products and may cause pressurization

Nitriles can be hydrolyzed to carboxylate salts and toxic, flammable ammonia gas by heating them with strong bases (Loudon, Marc. 2002. Organic Chemistry. 4th ed. New York: Oxford University Press. p. 956). This reaction is unlikely to happen with weak bases, but if it does, it is not expected to generate a hazardous amount of heat (less than 100 cal/gram). Further research of comparable examples in the literature or very small scale, carefully controlled experiments may be needed to fully assess compatibility.

Potential Gas Byproducts

• Ammonia (NH3)