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Hazard Predictions

• Generates heat: Exothermic reaction at ambient temperatures (releases heat)

Diethyl sulfate reacts violently with potassium tert-butoxide (Lewis, R.J., Sr. 2000. Sax's Dangerous Properties of Industrial Materials, 10th Edition. New York: John Wiley & Sons, pp. 1297; Bretherick, L. 1996. Bretherick's Handbook of Reactive Chemical Hazards. Fifth Ed. Urben, P.G., Ed. Butterworth-Heinemann, Boston, MA. Vol. 1, p 567).

When diethyl sulfate is mixed with aqueous bases, hydrolysis generates sulfuric acid, which can react further with the base (Lewis, R.J., Sr. 2000. Sax's Dangerous Properties of Industrial Materials, 10th Edition. New York: John Wiley & Sons, pp. 1297).