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Hazard Predictions

• Generates heat: Exothermic reaction at ambient temperatures (releases heat)
• Intense or explosive reaction: Reaction may be particularly intense, violent, or explosive

Reaction of glycerol and ethylene oxide is exothermic, and can accelerate to explosion (Anon. 1979. Loss Prevention Bulletin (028):92-93).

Ethylene oxide has an undefined incompatibility with alcohols (Lewis, R.J., Sr. 1992. Sax's Dangerous Properties of Industrial Materials, 8th Edition. New York: Van Nostrand Reinhold. pp. 1611).

Reaction between epoxides and alcohols require acid catalysts to occur at any appreciable rate (T. W. G. Solomons, C. B. Fryhle., Solomons & Fryhle's Organic Chemistry. 8th ed.; John Wiley & Sons, Inc., New York, 2004).