Reactivity Documentation
Epoxides |
mixed with |
Oximes |
Summary
- Generates heat: Exothermic reaction at ambient temperatures (releases heat)
Details
Reactivity Predictions (for each pair of reactive groups)
Epoxides
mixed with
Oximes
Oximes
Hazard Predictions
- Generates heat: Exothermic reaction at ambient temperatures (releases heat)
Epoxide rings can be opened with oximes when catalyzed by a base such as an amine or hydroxide. The product is a beta-hydroxy oxime O-ether, which may have biological activity. This reaction can occur at room temperature in some cases (Rad, M. N. S., Behrouz, S., Dianat, M., Synthesis, 2008, No. 13, pp 2055-2064x).