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Hazard Predictions

• Flammable: Reaction products may be flammable
• Generates gas: Reaction liberates gaseous products and may cause pressurization
• Generates heat: Exothermic reaction at ambient temperatures (releases heat)
• Intense or explosive reaction: Reaction may be particularly intense, violent, or explosive
• Toxic: Reaction products may be toxic

LiAlH4 and NaBH4 reduce acid chlorides to flammable alcohols (Kammermeier, B. 2012. Reduction. Ullmann's Encyclopedia of Industrial Chemistry. (Online)).

Tributyl tin hydride (Bu3SnH) and lithium aluminum tri(tert-butoxide) hydride (LiAlH(O-t-C4H9)3) reduce acid chlorides to aldehydes, which may be toxic, volatile, and flammable (Eggeman, T. 2001. Hydrides. In Kirk-Othmer Encyclopedia of Chemical Technology. John Wiley & Sons, Inc. (Online); Kammermeier, B. 2012. Reduction. Ullmann's Encyclopedia of Industrial Chemistry. (Online)).

The reaction of methylmagnesium iodide and thiophosphoryl chloride is highly exothermic and can easily cause an explosion if not adequately controlled (Davies, S.G., Chem. Brit., 1984, 20, 403; Bercaw, J. E., Chem. Eng. News, 1984, 62(18), 4).

Alkylation of acyl halides with dialkylzinc compounds is exothermic and can lead to an explosion if the reaction is too fast or uncontrolled (Methoden der Organischen Chemie; Muller, E. (Ed.); Stuttgart, Thieme, 1973, Vol. 13.2a, p. 781).

Titanium hydride reacts with acid fluoride solutions at elevated temperatures (Sullivan, E. and Wade, R. 1980. Hydrides. Kirk-Othmer Encyclopedia of Chemical Technology, 3rd ed. John Wiley & Sons, Inc.).

Depending on the conditions, lithium aluminum hydride can reduce sulfonyl chlorides to sulfinic acids or thiols (Kammermeier, B. 2000. Reduction. Ullmann's Encyclopedia of Industrial Chemistry. (Online)).

Potential Gas Byproducts

• Alcohols
• Aldehydes
• Phosphine (PH3)