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Hazard Predictions

• Generates heat: Exothermic reaction at ambient temperatures (releases heat)

Acyl halides are highly susceptible to nucleophilic attack (Loudon, Marc. 2002. Organic Chemistry. 4th ed. New York: Oxford University Press. p. 957-962). They may undergo nucleophilic attack by weak bases. This reaction would produce substituted carbonyl compounds and halide salts.

If any water is present, it will also react with the acyl halide to generate carboxylic acid and HX gas, which can react exothermically with the remaining base. Caution should be used before proceeding. Further research of comparable examples in the literature or very small scale, carefully controlled experiments may be needed to fully assess compatibility.