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Reactivity Documentation

Amines, Phosphines, and Pyridines

mixed with

Amides and Imides

Summary

Details

Amines, Phosphines, and Pyridines is a reactive group.
Amides and Imides is a reactive group.

Reactivity Predictions (for each pair of reactive groups)

Amides and Imides mixed with
Amines, Phosphines, and Pyridines

Hazard Predictions

Urea or N-alkylureas release NH3 gas when heated with primary amines, especially aromatic amines (Coffey, S., Ed. Rodd's Chemistry of carbon compounds; a modern comprehensive treatise, Second edition. New York: Elsevier Publishing Company, 1965. Vol. I, Part C, pp. 311-312).

Ethylamine and caprolactam (a cyclic amide) undergo a violent reaction when mixed (Pohanish, Richard P.; Greene, Stanley A. (2009). Wiley Guide to Chemical Incompatibilities (3rd Edition). John Wiley & Sons. p. 451-2.)

Thionamides may react with amines, anilines, hydrazine, and ammonium hydroxide to liberate toxic and flammable H2S gas (Smith, P. A. S., Open-Chain Nitrogen Compounds, Vol. I. New York: W. A. Benjamin, Inc., 1965, pp. 162).

Potential Gas Byproducts