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Reactivity Documentation

Acetals, Ketals, Hemiacetals, and Hemiketals

mixed with

Epoxides

Summary

Details

Epoxides is a reactive group.

Reactivity Predictions (for each pair of reactive groups)

Epoxides mixed with
Acetals, Ketals, Hemiacetals, and Hemiketals

Hazard Predictions

Epoxides are known to react with alcohols, as shown in the following examples. Acetals have alcohol-like structures, and are likely to react in a similar way to alcohols.

Reaction of glycerol and ethylene oxide is exothermic, and can accelerate to explosion (Anon. 1979. Loss Prevention Bulletin (028):92-93).

Ethylene oxide has an undefined incompatibility with alcohols (Lewis, R.J., Sr. 1992. Sax's Dangerous Properties of Industrial Materials, 8th Edition. New York: Van Nostrand Reinhold. pp. 1611).

Reaction between epoxides and alcohols require acid catalysts to occur at any appreciable rate (T. W. G. Solomons, C. B. Fryhle., Solomons & Fryhle's Organic Chemistry. 8th ed.; John Wiley & Sons, Inc., New York, 2004).